‚ÄčMETABOLISM AND EXCRETION

  • Metformin does not undergo hepatic metabolism or biliary excretion.
    • No metabolites have been found in humans.

  • Renal clearance is 3.5 times greater than creatinine clearance.
    • This indicates that tubular secretion is predominant.

  • 90% of absorbed drug is eliminated renally.